Produced using AFYX Therapeutics’ proprietary formulation and the electrospinning manufacturing technique, the Rivelin patch is comprised of two layers: an adhesive drug-delivery layer and a backing layer.
The drug-delivery layer possesses a unique structure made of nanoscale and microscale fibers with high porosity and surface area, which facilitates patch adhesion to the mucosal lining. The adhesiveness of the layer only manifest when in contact with a moist surface, minimizing the risk of drug exposure elsewhere when handling the patch.
The drug is incorporated into the fibers during manufacturing, and it is released after application to the site in need. This results in a prolonged interaction with the tissues and a sustained release, which enhances drug bioavailability.
The impermeable backing layer prevents drug release into any other areas than those intended and drives drug penetration into the target lesion. The backing layer also facilitates the easy application of the patch by the patient, for example by preventing the patch from sticking to the fingers.
The result is a flexible, biocompatible, mucoadhesive patch that releases a therapeutic over a significant period of adhesion.